Critical miRNAs in regulating pulmonary hypertension: A focus on Signaling pathways and therapeutic Targets

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成果类型：

期刊论文

作者：

Wang, Di;Luo, Meng-Yi;Tian, Ying;Zhang, Jing;Liang, Na;...

通讯作者：

Wang, AP;Gong, SX

作者机构：

[Li, Nan-Ping; Zhang, Jing; Wang, Ai-Ping; Luo, Meng-Yi; Wang, Di] Univ South China, Inst Neurosci Res, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Gong, Shao-Xin; Gong, SX] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Ai-Ping; Tian, Ying; Luo, Meng-Yi] Univ South China, Affiliated Nanhua Hosp, Inst Clin Res, Hengyang Med SchDept Clin Lab, Hengyang 421002, Hunan, Peoples R China.

[Li, Nan-Ping; Liang, Na] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Anesthesiol, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Wang, AP ; Gong, SX ] U

Univ South China, Inst Neurosci Res, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Class of effect;Pulmonary hypertension;Vascular remodeling;miRNAs

期刊：

Analytical Biochemistry

ISSN：

0003-2697

年：

2023

卷：

675

页码：

115228

DOI：

10.1016/j.ab.2023.115228

基金类别：

This project was supported by the National Natural Science Foundation of China [grant number 81600040 to Wang AP, 31871169 to Tian Y], Innovation guidance project of Hunan Province [grant number 2018SK51606 to Gong SX], and the Natural Science Foundation of the Province of Hunan [grant number 2021JJ30601 to Wang AP], Key Program of Education Department of Hunan Province [grant number 21A0274 to Wang AP].

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Pulmonary hypertension (PH) is complex disease as a result of obstructive pulmonary arterial remodeling, which in turn results in elevated pulmonary arterial pressure (PAP) and subsequent right ventricular heart failure, eventually leading to premature death. However, there is still a lack of a diagnostic blood-based biomarker and therapeutic target for PH. Because of the difficulty of diagnosis, new and more easily accessible prevention and treatment strategy are being explored. New target and diagnosis biomarkers should also allow for early diagnosis. In biology, miRNAs are short endogenous ...

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Critical miRNAs in regulating pulmonary hypertension: A focus on Signaling pathways and therapeutic Targets

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