Effects of rosiglitazone on the proliferation of vascular smooth muscle cell induced by high glucose

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成果类型：

期刊论文

作者：

Ling, Hong-Yan;Hu, Bi;Wang, Bing-Xiang;Zu, Xu-Yu;Feng, Shui-Dong;...

通讯作者：

Liao, Duan-Fang

作者机构：

[Ling, Hong-Yan; Liao, Duan-Fang] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Ou, He-Sheng; Liao, Duan-Fang; Zu, Xu-Yu] Univ S China, Inst Pharm & Pharmacol, Div Pharmacoprote, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Shou-Hong; Ling, Hong-Yan; Hu, Bi] Univ S China, Dept Physiol, Hengyang 421001, Peoples R China.

[Wang, Bing-Xiang] Taishan Med Collage, Dept Physiol, Tai An 271000, Shandong, Peoples R China.

[Feng, Shui-Dong] Univ S China, Dept Epidemiol, Hengyang 421001, Peoples R China.

通讯机构：

[Liao, Duan-Fang] U

Univ S China, Inst Pharm & Pharmacol, Div Pharmacoprote, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Cell cycle;High glucose;MMP-2;Rosiglitazone;VSMC

期刊：

Cardiovascular Drugs and Therapy

ISSN：

0920-3206

年：

2008

卷：

期：

页码：

453-460

DOI：

10.1007/s10557-008-6127-6

基金类别：

Acknowledgments The authors are indebted to Dr. Xuefeng Xia (University of Texas-Houston Health Science Center) for his valuable help in the preparation of the manuscript. This study was supported by grants from the Department of Education of Hunan Province (NO. 05C465), the National Natural Science Foundation of China (30770868), the National Major Basic Research Program (973 program) (2006CB503808) and the Natural Science Foundation of Hunan Province (NO. 01JJY2147).

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

AIM: To investigate the effects of the sensitizer rosiglitazone on the proliferation of vascular smooth muscle cell (VSMC) induced by high glucose administration. METHODS: VSMCs were isolated from rat thoracic aortas and cultured in 10% fetal bovine serum (FBS). VSMC proliferation was evaluated by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cell counting. The cell cycle was examined by flow cytometry. The protein expressions of proliferating cell nuclear antigen (PCNA) and matrix metalloproteinases-2 (MMP-2) were evaluated by Western blotting. MMP-2 mRNA expression was analyzed...

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Effects of rosiglitazone on the proliferation of vascular smooth muscle cell induced by high glucose

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