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RNA-Binding Domain is Necessary for PprM Function in Response to the Extreme Environmental Stress in Deinococcus radiodurans

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成果类型:
期刊论文
作者:
Li, Wei;Ma, Yun;Yang, Jie;Xiao, Fangzhu;Wang, Wuzhou;...
通讯作者:
He, Shuya
作者机构:
[Li, Wei] Cent South Univ, Xiangya Hosp, Dept Geriatr, Changsha, Hunan, Peoples R China.
[Wang, Wuzhou; He, Shuya; Li, Wei; Xiao, Fangzhu; Yang, Jie; Ma, Yun] Univ South China, Dept Biochem & Biol, Hengyang, Peoples R China.
通讯机构:
[He, Shuya] U
Univ South China, Dept Biochem & Biol, Hengyang, Peoples R China.
语种:
英文
关键词:
Deinococcus radioduran;PprM;Environmental stress;RNA-binding domain
期刊:
Indian Journal of Microbiology
ISSN:
0046-8991
年:
2017
卷:
57
期:
4
页码:
492-498
基金类别:
Acknowledgements This work was supported by funding from the National Natural Science Foundation of China (Grant No. 81272993).
机构署名:
本校为通讯机构
院系归属:
药学与生物科学学院
摘要:
Deinococcus radiodurans was considered as one of the most radiation-resistant organisms on Earth because of its strong resistance to the damaging factors of both DNA and protein, including ionizing radiation, ultraviolet radiation, oxidants, and desiccation. PprM, as a bacterial cold shock protein homolog, was involved in the radiation resistance and oxidative stress response of D. radiodurans, but its potential mechanisms are poorly expounded. In this study, we found that PprM was highly conserved with the RNA-binding domain in Deinococcus gen...

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