Pyroptosis in microbial infectious diseases

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成果类型：

期刊论文

作者：

Xiao, Cui;Cao, Saihong;Li, Yunfei;Luo, Yuchen;Liu, Jian;...

通讯作者：

Bai, Qinqin;Chen, LL

作者机构：

[Bai, Qinqin; Li, Yunfei; Xiao, Cui; Chen, Lili; Liu, Jian; Cao, Saihong; Luo, Yuchen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.

[Cao, Saihong] Yiyang Med Coll, Sch Publ Hlth & Lab Med, Yiyang 421000, Hunan, Peoples R China.

[Chen, Yuyu] Cent South Univ, Affiliated Canc Hosp, Hunan Canc Hosp, Xiangya Sch Med,Infect Associated Hemophagocyt Syn, Changsha 421000, Hunan, Peoples R China.

通讯机构：

[Bai, QQ; Chen, LL ] U

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Pyroptosis;Gasdermins;Caspases;Inflammasomes;Microbial infections;Therapeutic strategies

期刊：

Molecular Biology Reports

ISSN：

0301-4851

年：

2024

卷：

期：

页码：

1-14

DOI：

10.1007/s11033-023-09078-w

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province (2020JJ4527, 2023JJ30501, 2023JJ30502) and the Scientific Research Fund of Hunan Provincial Education Department (21B0399).

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Pyroptosis is a gasdermins-mediated programmed cell death that plays an essential role in immune regulation, and its role in autoimmune disease and cancer has been studied extensively. Increasing evidence shows that various microbial infections can lead to pyroptosis, associated with the occurrence and development of microbial infectious diseases. This study reviews the recent advances in pyroptosis in microbial infection, including bacterial, viral, and fungal infections. We also explore potential therapeutic strategies for ...

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