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Stability and Hopf bifurcation of a HIV infection model with CTL-response delay

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成果类型:
期刊论文
作者:
Zhu, Huiyan*;Luo, Yang;Chen, Meiling
通讯作者:
Zhu, Huiyan
作者机构:
[Zhu, Huiyan; Chen, Meiling] Univ S China, Coll Math Phys, Hengyang 421001, Hunan, Peoples R China.
[Luo, Yang] Univ S China, Coll Comp Sci & Technol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zhu, Huiyan] U
Univ S China, Coll Math Phys, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
HIV infection;Delayed immune response;Stability;Hopf bifurcation
期刊:
Computers & Mathematics with Applications
ISSN:
0898-1221
年:
2011
卷:
62
期:
8
页码:
3091-3102
基金类别:
Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [11JJ9001]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11071060]; Hunan Provincial Science & Technology Department [2010GK3013]
机构署名:
本校为第一且通讯机构
院系归属:
计算机科学与技术学院
数理学院
摘要:
In this paper, we consider a HIV infection model with CTL-response delay and analyze the effect of time delay on stability of equilibria. We obtain the global stability of the infection-free equilibrium and give sufficient conditions for the local stability of the CTL-absent equilibrium and CTL-present equilibrium. By choosing the CTL-response delay τ as a bifurcation parameter, we prove that the CTL-present equilibrium is locally asymptotically stable in a range of delays and a Hopf bifurcation occurs as τ crosses a critical value. Numerical...

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