In Situ Formation of Hydrogel Wound Dressing Based on Carboxymethyl Chitin/Tannic Acid for Promoting Skin Wound Healing

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成果类型：

期刊论文

作者：

Lin, Jinhui;Li, Siyaqi;Ying, Yunfei;Zheng, Weilin;Wu, Jingcheng;...

通讯作者：

Wang, Peiyuan;Liu, XL

作者机构：

[Ying, Yunfei; Liu, Xiaolong; Wang, Peiyuan; Liu, XL; Lin, Jinhui; Li, Siyaqi] Chinese Acad Sci, Key Lab Design & Assembly Funct Nanostruct, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China.

[Liu, Xiaolong; Wang, Peiyuan; Liu, XL; Lin, Jinhui; Li, Siyaqi] Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China.

[Ying, Yunfei] Univ South China, Dept Biochem & Mol Biol, Crit Human Dis Prevent Hunan Prov Dept Educ, Key Lab Ecol Environm,Sch Basic Med,Hunan Prov Coo, Hengyang 421001, Peoples R China.

[Zheng, Weilin] Huaqiao Univ, Sch Med, Quanzhou 362021, Fujian, Peoples R China.

[Zheng, Weilin] Huaqiao Univ, Sch Biomed Sci, Quanzhou 362021, Fujian, Peoples R China.

通讯机构：

[Wang, PY; Liu, XL ] C

Chinese Acad Sci, Key Lab Design & Assembly Funct Nanostruct, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China.

Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China.

Hosp Fujian Med Univ, United Innovat Mengchao Hepatobiliary Technol Key, Mengchao Hepatobiliary, Fuzhou 350025, Peoples R China.

语种：

英文

期刊：

ACS OMEGA

ISSN：

2470-1343

年：

2024

卷：

期：

页码：

4386-4394

DOI：

10.1021/acsomega.3c06683

基金类别：

XMIREM autonomously deployment project [FJHJF-L-2022-2]; Special Fund Project for Fujian Marine Economic Development in 2022 [2023CX12]; XMIREM autonomously deployment project [XKLEC2021KF04]; Research Fund of Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer & Xiamen Key Laboratory of Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine

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本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Triggering the healing process of drug-resistant bacteria-infected wounds has attracted great attention due to global morbidity that may induce gangrene, amputation, and even death. Here, a chitin derivative, carboxymethyl chitosan (CMC), tannic acid (TA), and Cu(2+) were used for hydrogel engineering. Using sodium bicarbonate as the neutralizer and reductant, hydrogen bonds between CMC and TA and in situ Cu(OH)(2) generation via ion coordination force between Cu(2+) and TA facilitated the synthesis of CMC/TA/Cu hydrogel. Cu(2+) and TA release, cytotoxicity, in vitro cell migration, angiogenes...

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In Situ Formation of Hydrogel Wound Dressing Based on Carboxymethyl Chitin/Tannic Acid for Promoting Skin Wound Healing

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