PRMT2 inhibits the formation of foam cell induced by ox-LDL in RAW 264.7 macrophage involving ABCA1 mediated cholesterol efflux

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成果类型：

期刊论文

作者：

Li, Yue-yan;Zhou, Shou-hong;Chen, Shan-shan;Zhong, Jing*;Wen, Ge-bo*

通讯作者：

Zhong, Jing;Wen, Ge-bo

作者机构：

[Zhong, J; Wen, GB; Zhong, Jing; Wen, Ge-bo; Li, Yue-yan] Univ South China, Inst Clin Med, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Li, Yue-yan] Univ South China, Dept Cardiovasc Med, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Shou-hong] Guilin Med Univ, Basic Med Coll, Dept Physiol, Guilin 541199, Guangxi, Peoples R China.

[Zhou, Shou-hong] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin 541199, Guangxi, Peoples R China.

[Chen, Shan-shan] Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhong, J; Wen, GB] U

Univ South China, Inst Clin Med, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ATP binding cassette transporter A1;Atherosclerosis;Cholesterol efflux;Foam cell;Protein arginine methyltransferase 2

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2020

卷：

524

期：

页码：

77-82

DOI：

10.1016/j.bbrc.2020.01.040

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81773294, 81472608]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ20014]; Chuanshan Talent Project of the University of South China [CS2018-3-35]; Open Project of Guangxi Key Laboratory of Brain and Cognitive Neuroscience [GKLBCN20190105-02]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Objectives: Protein arginine methyltransferase 2 (PRMT2) is closely related to the occurrence and development of atherosclerosis. However, its underlying mechanisms remain to be elucidated. The purpose of this study is to observe the effect of overexpression of PRMT2 on the formation of foam cells and to explore its possible mechanism in RAW 264.7 macrophage. Methods: Lentivirus vector of overexpression PRMT2 (LV-PRMT2) was constructed. LV-PRMT2 and lentivirus vector GV492 were transfected into RAW 264.7 macrophages, positive clone cells were s...

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PRMT2 inhibits the formation of foam cell induced by ox-LDL in RAW 264.7 macrophage involving ABCA1 mediated cholesterol efflux

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