INTRODUCTION: The interaction between endothelial cells can regulate hemostasis, vasodilation, as well as immune and inflammatory responses. Excessive loading on the endothelial cells leads to endothelial damage and endothelial barrier dysfunction. Understandingandmasteringthe dynamic nature of cell-cell rupture plays a crucial role in exploring the practical applications related to tumor destruction, vascular remodeling, and drug delivery byemploying cavitation-induced damage tosoft tissues. METHODS: To investigate the damage mechanisms of endothelial cellular networks under ultrasound cavita...