Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway

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成果类型：

期刊论文

作者：

Dao, Ji-Ji;Zhang, Wei;Liu, Chong;Li, Qian;Qiao, Chen-Meng;...

通讯作者：

Zhao, WJ;Chen, SX

作者机构：

[Li, Qian; Liu, Chong; Zhao, Wei-Jiang; Dao, Ji-Ji; Zhang, Wei; Zhao, WJ] Jiangnan Univ, Wuxi Sch Med, Cell Biol Dept, Wuxi, Jiangsu, Peoples R China.

[Li, Qian; Cui, Chun; Liu, Chong; Shen, Yan-Qin; Zhao, Wei-Jiang; Dao, Ji-Ji; Zhao, WJ; Qiao, Chen-Meng] Jiangnan Univ, MOE Med Basic Res Innovat Ctr Gut Microbiota & Chr, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China.

[Zhang, Wei] Guizhou Nursing Vocat Coll, Dept Pathogen Biol, Guiyang, Guizhou, Peoples R China.

[Cui, Chun; Shen, Yan-Qin; Qiao, Chen-Meng] Jiangnan Univ, Wuxi Sch Med, Lab Neurodegenerat & Neuroinjury Dis, Wuxi, Jiangsu, Peoples R China.

[Chen, SX; Chen, Shuang-Xi] Univ South China, Affiliated Hosp 1, Multi Res Ctr Brain Disorders, Hengyang Med Sch,Dept Neurol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Chen, SX ] U

[Zhao, WJ ] J

Jiangnan Univ, Wuxi Sch Med, Cell Biol Dept, Wuxi, Jiangsu, Peoples R China.

Jiangnan Univ, MOE Med Basic Res Innovat Ctr Gut Microbiota & Chr, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China.

Univ South China, Affiliated Hosp 1, Multi Res Ctr Brain Disorders, Hengyang Med Sch,Dept Neurol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

D-galactose;ErbB4 receptor;ferroptosis;hippocampus;neurodegenerative diseases;neuron;senescence;small molecule

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2025

卷：

页码：

1528604

DOI：

10.3389/fphar.2025.1528604

基金类别：

Jiangsu Province Shuangchuang Talent Plan [JSSCRC 2021533]; National Natural Science Foundation of China [82301581]; Research Start-up Fund of Jiangnan University [1285081903200020]; Guizhou Nursing Vocational College Foundation [gzhlyj2023-04]; Science and Technology Foundation of Guizhou Provincial Health Committee [gzwkj2022-518]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Neuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing a significant role. This study aims to investigate the role of ErbB4 receptor activation in preventing D-Galactose (D-gal)-induced neuronal senescence. METHODS: Mice subjected to D-gal-induced aging were administered a small molecule ErbB4 receptor agonist (E4A), identified via virtual screening, melatonin, or a combination of both. Behavioral assessments were conducted to evaluate therapeutic efficacy in memory and cognitive functions. Immunofluorescence staining, w...

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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway

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