PI3K/Akt/FoxO3a signaling mediates cardioprotection of FGF-2 against hydrogen peroxide-induced apoptosis in H9c2 cells

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成果类型：

期刊论文

作者：

Liu, Mi-Hua;Li, Guo-Hua;Peng, Li-Jun;Qu, Shun-Lin;Zhang, Yuan;...

通讯作者：

Tang, Zhi-Han;Jiang, Zhi-Sheng

作者机构：

[Tang, Zhi-Han; Liu, Mi-Hua; Peng, Li-Jun; Peng, Juan; Tang, ZH; Jiang, ZS; Luo, Xin-Yuan; Tang, Hui; Jiang, Zhi-Sheng; Ren, Zhong; Qu, Shun-Lin; Li, Guo-Hua; Liu, Lu-Shan] Univ South China, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Tang, Zhi-Han; Liu, Mi-Hua; Peng, Li-Jun; Peng, Juan; Tang, ZH; Jiang, ZS; Luo, Xin-Yuan; Tang, Hui; Jiang, Zhi-Sheng; Ren, Zhong; Qu, Shun-Lin; Li, Guo-Hua; Liu, Lu-Shan] Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Liu, Mi-Hua] Univ South China, Dept Clin Lab, Affiliated Nanhua Hosp, Hengyang 421001, Hunan, Peoples R China.

[Peng, Li-Jun] Univ South China, Pediat Acad, Dept Sci & Educ, Changsha 410007, Peoples R China.

[Zhang, Yuan] Univ South China, Dept Pathol, Affiliated Mawangdui Hosp, Changsha 410016, Peoples R China.

通讯机构：

[Tang, ZH; Jiang, ZS] U

Univ South China, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

2 morpholino 8 phenylchromone;BIM protein;fibroblast growth factor 2;hydrogen peroxide;phosphatidylinositol 3 kinase;protein kinase B;recombinant fibroblast growth factor 2;recombinant protein;transcription factor FKHRL1;unclassified drug;Bcl2l11 protein, rat;BIM protein;fibroblast growth factor 2;Foxo3a protein, rat;hydrogen peroxide;phosphatidylinositol 3 kinase;protein kinase B;transcription factor FKHRL1;apoptosis;Article;cell damage;controlled study;drug antagonism;drug effect;drug mechanism;flow cytometry;H9c2 cell line;heart muscle cell;heart protection;immunoblotting;MTT assay;protein expression;protein phosphorylation;signal transduction;Western blotting;animal;apoptosis;cardiac muscle cell;cell line;drug effects;metabolism;phosphorylation;physiology;protein transport;rat;Animals;Apoptosis;Bcl-2-Like Protein 11;Cell Line;Fibroblast Growth Factor 2;Forkhead Box Protein O3;Hydrogen Peroxide;Myocytes, Cardiac;Phosphatidylinositol 3-Kinases;Phosphorylation;Protein Transport;Proto-Oncogene Proteins c-akt;Rats

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2016

卷：

414

期：

1-2

页码：

57-66

DOI：

10.1007/s11010-016-2658-5

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (81470435, 81170277, ZS Jiang), Specialized Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (20124324110003,ZS Jiang), the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (2008-244, ZS Jiang), Applied Basic Research Project of the Department of Science and Technology of Hunan Province(2014FJ6088, LJ Peng), Health Department of Hunan province 2011 annual scientific research project(B2011-041), Graduate student research innovation project of Hunan province (CX2013B397), and Hunan province college students inquiry learning and innovative experimental project in 2010 (No:475).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

船山学院

摘要：

Cardiovascular disease is a growing major global public health problem. Oxidative stress is regarded as one of the key regulators of pathological physiology, which eventually leads to cardiovascular disease. However, mechanisms by which FGF-2 rescues cells from oxidative stress damage in cardiovascular disease is not fully elucidated. Herein this study was designed to investigate the protective effects of FGF-2 in H2O2-induced apoptosis of H9c2 cardiomyocytes, as well as the possible signaling pathway involved. Apoptosis of H9c2 cardiomyocytes was induced by H2O2 and assessed using methyl thia...

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PI3K/Akt/FoxO3a signaling mediates cardioprotection of FGF-2 against hydrogen peroxide-induced apoptosis in H9c2 cells

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