National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372579]; Hunan Provincial Innovation Foundation For Postgraduate [2015SCX29]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target of rapamycin pathway in anticancer drug-resistant tumors. The present study demonstrated the roles of ABC translation protein alterations in the acquisition of the Adriamycin (ADM)-resistant phenotype of MCF-7 human breast cells. ...
