This study was supported by the grants from the National Natural Science Foundation of China (no. 81372579), the Hunan Provincial Innovation Foundation For Postgraduate (no. 2015SCX29) and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study.
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target of rapamycin pathway in anticancer drug-resistant tumors. The present study demonstrated the roles of ABC translation protein alterations in the acquisition of the Adriamycin (ADM)-resistant phenotype of MCF-7 human breast cells. ...
