期刊论文

Tian, SW

英文

Neuroscience

0306-4522

2024

542

11-20

10.1016/j.neuroscience.2024.02.003

This work was supported by the National Natural Science Foundation of China (32160197, 32260200), and the Guangxi Natural Science Foundation (2020GXNSFAA159001, 2020GXNSFAA297134). The funding sources had no further role. CRediT authorship contribution statement Liang Zhang: Methodology, Visualization, Formal analysis, Writing–original draft. Jing Zheng: Methodology, Visualization, Formal analysis, Writing–original draft. Shi-Yan Liu: Methodology, Visualization, Formal analysis, Writing–original draft. Li-Li Hou: Writing–original draft. Bo Zhang: Writing–review & editing, acquisition. Shao-Wen Tian: Conceptualization, Writing–review & editing, acquisition, Supervision.

本校为其他机构

acts as an important metabolic substrate and signalling molecule modulating neural activities in the brain, and recent preclinical and clinical studies have revealed its antidepressant effect after acute or chronic peripheral administration. However, the neural mechanism underlying the antidepressant effect of lactate, in particular when lactate is acutely administered remains largely unknown. In the current study, we focused on forced swimming test (FST) to elucidate the neural mechanisms through which acute intracerebroventricular (ICV) infusion of lactate exerts antidepressant-like effect. ...