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SOX1Promoter Hypermethylation as a Potential Biomarker for High-Grade Squamous Intraepithelial Neoplasia Lesion and Cervical Carcinoma: A Meta-Analysis With Trial Sequential Analysis

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成果类型:
期刊论文
作者:
Huang, Jin;Gao, Hong;Tan, Hong-Zhuan*
通讯作者:
Tan, Hong-Zhuan
作者机构:
[Huang, Jin; Gao, Hong; Tan, Hong-Zhuan] Cent South Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Peoples R China.
[Gao, Hong] Univ South China, Sch Nursing, Hengyang, Peoples R China.
通讯机构:
[Tan, Hong-Zhuan] C
Cent South Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Peoples R China.
语种:
英文
关键词:
cervical cancer;DNA Methylation;Sox1;Meta-analaysis;diagnosis;Trail sequential analysis;intra-epithelial lesion
期刊:
Frontiers in Genetics
ISSN:
1664-8021
年:
2020
卷:
11
页码:
486635
机构署名:
本校为其他机构
院系归属:
护理学院
摘要:
Background: DNA methylation has been widely assessed as a potential biomarker for the early detection of cervical cancer (CC). Herein, we assessed the associations of SOX1 promoter hypermethylation with squamous intraepithelial lesion and CC. Methods: Published studies and genome-wide methylation datasets were searched from electronic databases (up to April 2019). The associations of SOX1 hypermethylation with high-grade squamous intraepithelial lesion (HSIL) and CC risks were evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). T...

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