A Novel Tyrosine-Heme C-O Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins

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成果类型：

期刊论文

作者：

Yan, Dao-Jing;Li, Wei;Xiang, Yu;Wen, Ge-Bo;Lin, Ying-Wu*;...

通讯作者：

Lin, Ying-Wu

作者机构：

[Lin, Ying-Wu; Yan, Dao-Jing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Li, Wei; Tan, Xiangshi] Fudan Univ, Dept Chem, Inst Biomed Sci, Shanghai 200433, Peoples R China.

[Xiang, Yu] Tsinghua Univ, Dept Chem, Beijing 100083, Peoples R China.

[Wen, Ge-Bo; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.

[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Changsheng Rd 28, Hengyang 421001, Peoples R China.

通讯机构：

[Lin, Ying-Wu] U

Univ South China, Sch Chem & Chem Engn, Changsheng Rd 28, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

crosslinking;crystal structure;heme protein;post-translational modification;tyrosine-heme

期刊：

ChemBioChem

ISSN：

1439-4227

年：

2015

卷：

期：

页码：

47-50

DOI：

10.1002/cbic.201402504

基金类别：

National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [31370812, 31270869]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2015JJ1012]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

摘要：

Heme post-translational modification plays a key role in tuning the structure and function of heme proteins. We herein report a novel tyrosine-heme covalent C-O bond in an artificially produced sperm whale myoglobin (Mb) mutant, F43Y Mb, which formed spontaneously in vivo between the Tyr43 hydroxy group and the heme 4-vinyl group. This highlights the diverse chemistry of heme post-translational modifications, and lays groundwork for further investigation of the structural...

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A Novel Tyrosine-Heme C-O Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins

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