STS loaded PCL-MECM based hydrogel hybrid scaffolds promote meniscal regeneration via modulating macrophage phenotype polarization

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成果类型：

期刊论文

作者：

Li, Muzhe;Yin, Han;Chen, Mingxue;Deng, Haotian;Tian, Guangzhao;...

通讯作者：

Guo, Quanyi(clear_ann@163.com);Chen, Zhiwei(czw9915@sina.com);Liu, Shuyun(doctorguo_301@163.com)

作者机构：

[Li, Muzhe; Yin, Han; Liu, Shuyun; Tian, Guangzhao; Guo, Quanyi; Deng, Haotian] Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Key Lab Musculoskeletal Trauma & War Injuries PLA, Med Ctr 1,Beijing Key Lab Regenerat Med Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.

[Chen, Zhiwei; Li, Muzhe; Yi, Guoliang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Orthoped, 69 Chuanshan Rd, Hengyang 421000, Hunan, Peoples R China.

[Chen, Mingxue] Peking Univ, Beijing Jishuitan Hosp, Dept Orthoped Surg, Clin Coll 4, Beijing 100035, Peoples R China.

[Guo, Weimin] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Guangdong Prov Key Lab Orthoped & Traumatol, 58 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China.

通讯机构：

[Quanyi Guo; Shuyun Liu] I

[Zhiwei Chen] D

Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China<&wdkj&>Department of Orthopedics, The First Affiliated Hospital, Hengyang Medical School, University of South China, No. 69, Chuanshan Road, Hengyang 421000, Hunan Province, China

语种：

英文

期刊：

BIOMATERIALS SCIENCE

ISSN：

2047-4830

年：

2023

卷：

期：

页码：

2759-2774

DOI：

10.1039/d2bm00526c

基金类别：

This work was supported by the National Natural Science Foundation of China (81972070, 82102552), the PLA Youth Project for Medical Science (18QNP057), the Key Project under the Guidance of Hunan Provincial Health Commission (20200476), and the Scientific Research Project of Hunan Provincial Health Commission (202102080160).

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摘要：

Meniscus injury has a limited ability to heal itself and often results in the progression to osteoarthritis. After a meniscus injury, there is an obvious acute or chronic inflammatory response in the articular cavity, which is not conducive to tissue regeneration. M2 macrophages are involved in tissue repair and remodeling. Regenerative medicine strategies for tissue regeneration by enhancing the phenotypic ratio of M2 : M1 macrophages have been demonstrated in a variety of tissues. However, there are no relevant reports in the field of meniscu...

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STS loaded PCL-MECM based hydrogel hybrid scaffolds promote meniscal regeneration via modulating macrophage phenotype polarization

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