期刊论文

Liang, F

英文

Drug Delivery and Translational Research

2190-393X

2024

14

1

143-157

10.1007/s13346-023-01388-7

This work was supported by the Excellent Youth Foundation of Hunan Provincial Department of Education (19B477), Project of Hunan Provincial Health Commission (20200018, 20200037), Natural Science Foundation of Hunan Province (2021JJ70043), and Guiding Project of Hengyang Science and Technology Bureau (202121034637).

本校为第一且通讯机构

The cardioprotective effect of microRNAs (miRNAs) on myocardial ischemic-reperfusion (I/R) injury has been documented. Here, we aim to decipher the mechanism of miR-24 delivered by human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUC-MSC-EVs) in myocardial I/R injury after dexmedetomidine (DEX) preconditioning. We collected and identified hUC-MSCs and extracted EVs, which were co-cultured with DEX-preconditioned hypoxia/reoxygenation (H/R) cardiomyocyte models or injected into I/R mouse models. The cardiomyocytes and myocardial injury were evaluated by molecular biolo...