Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Xinxin;Hou, Zixin;Han, Mingming;Chen, Kemin;Wang, Yuxia;...

通讯作者：

Yang, Fengrui

作者机构：

[Liu, Xinxin; Yang, Fengrui] Univ South China, Affiliated Huaihua Hosp, Dept Anesthesiol, 144 South Jinxi Rd, Huaihua 418000, Peoples R China.

[Chen, Kemin; Yang, Fengrui; Wang, Yuxia; Hou, Zixin; Qing, Jie] Univ South China, Dept Anesthesiol, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

[Han, Mingming] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Anesthesiol, Div Life Sci & Med, Hefei 230036, Anhui, Peoples R China.

[Han, Mingming] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Sch Med, Baltimore, MD 21287 USA.

通讯机构：

[Fengrui Yang] D

Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China<&wdkj&>Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China

语种：

英文

关键词：

Amygdala;Chronic restraint stress;Comorbid chronic pain;Depression-like behaviors;ERK-CREB-BDNF signaling Pathway;GABAergic neuron excitation;Salvianolic acid B

期刊：

Journal of Psychiatric Research

ISSN：

0022-3956

年：

2022

卷：

151

页码：

205-216

DOI：

10.1016/j.jpsychires.2022.04.014

基金类别：

Outstanding Youth Project of Hunan Provincial Department of Education [19B477]; Project of Hunan Pro-vincial Health Commission [20200018, 20200030]; Natural Science Foundation of Hunan Province [2021JJ70043]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Pain comorbid with depression occurred frequently in clinical settings. This study aims to explore the molecular mechanism underlying antidepressant and analgetic effect of salvianolic acid B (SalB) in comorbid pain in depression induced by chronic restraint stress (CRS), which associates with GABAergic neuron activation in the amygdala and the ERK-CREB-BDNF signaling pathway. The differentially expressed genes related to comorbid pain in CRS-induced depression were screened through bioinformatics analysis. After CRS treatment for 3 weeks, depression-like behaviors were developed in GAD2-tdT m...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问