Monitoring heat stroke with a HClO-activatable near-infrared fluorescent probe

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成果类型：

期刊论文

作者：

Li, Songjiao;Yang, Ke;Wang, Peipei;Liu, Ying;Cheng, Dan;...

通讯作者：

Dan Cheng<&wdkj&>Longwei He

作者机构：

[Liu, Ying; Yang, Ke; He, Longwei; Wang, Peipei; Li, Songjiao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang, Peoples R China.

[Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang, Peoples R China.

通讯机构：

[Dan Cheng] C

[Longwei He] H

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China

语种：

英文

关键词：

Fluorescent probe;Hypochlorous acid;Near-infrared;Lysosome targeting;Heat stroke

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2023

卷：

385

页码：

133696

DOI：

10.1016/j.snb.2023.133696

基金类别：

CRediT authorship contribution statement Songjiao Li: Methodology, Investigation, Data curation, Writing – original draft, acquisition. Ke Yang: Investigation, Formal analysis, Software. Peipei Wang: Formal analysis, Software. Ying Liu: Formal analysis, Software. Dan Cheng: acquisition, Validation, Writing – review & editing. Longwei He: Project administration, Supervision, Validation, acquisition, Writing – review & editing, Resources.

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Heat stroke is devastating pathology associated with a high morbidity and mortality rate. If heat cytotoxicity mechanisms are understood early, stroke-related diseases can be prevented or treated. Unfortunately, the details of lysosome's role in heat stroke remain poorly understood due to a lack of adequate tools. Recent studies indicate a correlation between lysosome HClO and the development of heat stroke. For better interpretation and treatment of heat stroke, the urgent and reliable real-time tools for tracking the correlation between HClO level and heat stroke is necessary. Herein, we pre...

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Monitoring heat stroke with a HClO-activatable near-infrared fluorescent probe

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