Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson\'s disease model by AMPK-mediated autophagy - 成果

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Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson's disease model by AMPK-mediated autophagy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wan, Juan;Gao, Yijiang;Tan, Jian;Yi, Shanqing;Huang, Kailiang;...

通讯作者：

Wu, H.;Chen, S.

作者机构：

[Liu, Yao; Wu, Heng; Chen, Shuangxi; Chang, Dong; Yi, Shanqing; Gao, Yijiang; Wan, Juan; Tan, Jian; Xie, Jiali] Univ South China, Hengyang Med Sch, Multiom Res Ctr Brain Disorders, Dept Neurol,Affiliated Hosp 1, Hengyang, Hunan, Peoples R China.

[Liu, Yao; Wu, Heng; Chen, Shuangxi; Chang, Dong; Yi, Shanqing; Gao, Yijiang; Wan, Juan; Tan, Jian; Xie, Jiali] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Clin Res Ctr Immune Related Encephalopathy Hunan, Hengyang, Hunan, Peoples R China.

[Huang, Kailiang] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Emergency, Hengyang, Hunan, Peoples R China.

[Chen, Shuangxi] Hlth Ctr Yumushan Town, Hengyang, Hunan, Peoples R China.

通讯机构：

[Chen, S.; Wu, H.] D

Department of Neurology, Hunan, China

语种：

英文

关键词：

AMPK;autophagy;mitochonic acid 5 (MA-5);Parkinson's disease (PD)

期刊：

FOLIA NEUROPATHOLOGICA

ISSN：

1641-4640

年：

2022

卷：

期：

页码：

329-337

DOI：

10.5114/fn.2022.118796

基金类别：

This research was funded by the Hunan Provincial Natural Science Foundation of China (grant nos. 2021JJ30624, 2021JJ70114), Scientific research project of Hunan Health Committee (grant nos. 20201911, 20201963), and Hunan Science and Technology Innovation Key Project (Grant no. 2020SK1013).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Parkinson's disease (PD) is a well-known neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, and oxidative stress and neuroinflammation are also associated with the pathogenesis of PD. Mitochonic acid 5 (MA-5), an analogue of indole-3-acetic acid, exerts key protective roles in inhibiting apoptosis, oxidative stress and neuroinflammation in multiple diseases. However, whether MA-5 can be beneficial for PD remains unclear. Hence, the aim of this study was to investigate the neuroprotective role of MA-5 in PD. In...

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Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson's disease model by AMPK-mediated autophagy

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