期刊论文

Yin, Wei-Dong

英文

Biochemical and Biophysical Research Communications

0006-291X

2014

443

2

428-434

10.1016/j.bbrc.2013.11.109

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81270269 , 81070220 , 81300158 and 81170278 ), and the Science and Technology Department of Hunan Province ( 2013FJ3027 ), and the Education Department of Hunan Province outstanding youth ( 13B103 ), and Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China ( 2008-244 ), and the construct program of the key discipline in Hunan Province.

本校为第一且通讯机构

Atherosclerosis is a lipid disorder disease characterized by chronic blood vessel wall inflammation driven by the subendothelial accumulation of macrophages. Studies have shown that lipoprotein lipase (LPL) participates in lipid metabolism, but it is not yet known whether post-transcriptional regulation of LPL gene expression by microRNAs (miRNAs) occurs in vivo. Here, we tested that miR-467b provides protection against atherosclerosis by regulating the target gene LPL which leads to reductions in LPL expression, lipid accumulation, progression...