A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter

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成果类型：

期刊论文

作者：

Xia, Zhidan;Tang, Biyao;Li, Xiaopeng;Li, Xinran;Jia, Yangfan;...

通讯作者：

Min, Junxia;Wang, FD

作者机构：

[Li, Xinran; Min, Junxia; Wang, Fudi; Tang, Biyao; Liu, Siyi; Jiang, Jianwei; Li, Xiaopeng; Song, Jingshu; Min, JX; Xia, Zhidan; Jia, Yangfan] Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Med,Sch Publ Hlth,State Key, Hangzhou, Peoples R China.

[Wang, Fudi; Tang, Biyao] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Peoples R China.

[Wang, Fudi; Tang, Biyao] Xinxiang Med Univ, Affiliated Hosp 1, Sch Publ Hlth, Sch Basic Med Sci, Xinxiang, Peoples R China.

[Song, Jingshu] Zhejiang Univ, Core Facil, Sch Med, Hangzhou, Peoples R China.

通讯机构：

[Wang, FD ; Min, JX] Z

Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Med,Sch Publ Hlth,State Key, Hangzhou, Peoples R China.

Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Peoples R China.

Xinxiang Med Univ, Affiliated Hosp 1, Sch Publ Hlth, Sch Basic Med Sci, Xinxiang, Peoples R China.

语种：

英文

期刊：

研究(英文)

ISSN：

2096-5168

年：

2024

卷：

页码：

0440

DOI：

10.34133/research.0440

基金类别：

National Natural Science Foundation of China [32371222, 32330047, 31930057, 31970689, 32200961]; Zhejiang University School of Public Health Interdisciplinary Research Innovation Team Development

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

The identification of aging- and longevity-associated genes is important for promoting healthy aging. By analyzing a large cohort of Chinese centenarians, we previously found that single-nucleotide polymorphisms (SNPs) in the SLC39A11 gene (also known as ZIP11) are associated with longevity in males. However, the function of the SLC39A11 protein remains unclear. Here, we found that SLC39A11 expression is significantly reduced in patients with Hutchinson-Gilford progeria syndrome (HGPS). In addition, we found that zebrafish with a mutation in slc39a11 that significantly reduces its expression h...

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A Novel Role for the Longevity-Associated Protein SLC39A11 as a Manganese Transporter

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