期刊论文

Tang, M

英文

Biochemical and Biophysical Research Communications

0006-291X

2025

781

152553

10.1016/j.bbrc.2025.152553

CRediT authorship contribution statement Yanxu Zhang: Writing – original draft, Methodology, Investigation. Yuting Zhong: Data curation, Conceptualization. Qun Zeng: Resources, Project administration. Min Tang: Writing – review & editing, Visualization, acquisition. information This work was supported by the Education Department of Hunan Province ( 20A418 ); National Natural Science Foundation of China ( 81711530050 )

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Cardiac fibrosis is a maladaptive response in which excessive extracellular matrix (ECM) deposition stiffens the myocardium and compromises systolic and diastolic function. Reactive oxygen species (ROS) sit at the hub of this process, acting as initiators and amplifiers of four key pro-fibrotic signaling cascades, including transforming growth factor-beta (TGF-β), mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-κB), and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt). Crosstalk among these pathways forms a self...