期刊论文

Bioinformatics Analysis of Chlamydia psittaci MIP Protein

中文

基因组学与应用生物学

1674-568X

2021

40

5

1976-1982

10.13417/j.gab.040.001976

81572011:国家自然科学基金 31600150:国家自然科学基金 2016JJ3103:湖南省自然科学基金青年项目 2018KJ110:衡阳市重点实验室项目 2905:湖南省大学生创新创业训练计划项目

本校为第一机构

为初步了解鹦鹉热衣原体（Chlamydia psittaci, Cps）巨噬细胞感染增强蛋白（macrophage infection potentiator, MIP）的生物学特征。本研究从美国国家生物技术信息中心（national center for biotechnology infor mation, NCBI）数据库中检索并下载全部Cps菌株的MIP基因序列,运用生物信息学软件分析Cps不同菌株间MIP基因的同源性,MIP蛋白的氨基酸序列、理化性质、跨膜区、信号肽、空间结构以及抗原表位。结果显示:MIP基因在Cps不同菌株间的同源性为98.96%～99.87%。生物信息学软件预测MIP蛋白为一种性质不稳定、弱酸性的亲水蛋白;该蛋白无跨膜区和信号肽;α螺旋与β转角是其主要结构特征;该蛋...

To investigate the biological characteristics of Macrophage infection potentiator (MIP) of Chlamydia psittaci. The MIP gene sequences of all C. psittaci strains were retrieved and downloaded from the national center for biotechnology information (NCBI). The homology of MIP genes was compared among different C. psittacis strains, and the amino acid sequence, physicochemical properties, transmembrane region, signal peptide, spatial structure and antigenic epitopes of MIP protein were analyzed with bioinformatics softwares. The results showed: the...