期刊论文

Study on Serum Metabonomics in Patients with Lung Cancer with Different Pathological Stages

中文

基因组学与应用生物学

1674-568X

2020

39

02

830-836

10.13417/j.gab.039.000830

湖南省教育厅科学研究项目（17C1389）资助；

本校为第一机构

肺癌是当今世界最常见的恶性肿瘤之一,其新发率和死亡率多年来都居于各类癌症之首,其中85％的肺癌都是非小细胞癌,而腺癌又是最常见的非小细胞癌.肺癌的高隐匿性是造成其高死亡率的最主要原因,因此为肺癌的早期诊断和病理分期寻求高效可靠的方法是十分必要的.代谢组学揭示了小分子代谢物的一系列变化,反映了生命活动的最终状态,因此也能直接反映疾病不同发展阶段的病理生理变化.本研究利用核磁共振氢谱(1H-NMR),对在我院就诊的27例不同病理分期的肺腺癌患者和13例健康志愿者进行了血清代谢物分析,运用正交偏最小二乘判别分析(OPLS-DA)对1H-NMR数据进行建模,单变量统计分析对模型进行评价.结果 表...

Lung cancer is one of the most common malignant tumors in the world. Its new incidence and mortality have been the top among cancers for many years. 85% of lung cancers are non-small cell lung cancer (NSCLC), and adenocarcinoma is the most common NSCLC. The high occultity of lung cancer is the most important cause of its high mortality. Therefore, it is necessary to find an efficient and reliable method for early diagnosis and pathological staging of lung cancer. Metabolomics reveals a series of changes in small molecule metabolites that reflect the final state of life activities, as well as d...