期刊论文

Bioinformatics Analysis of Human HLA-DPB1 Gene and Protein

中文

基因组学与应用生物学

1674-568X

2019

38

10

4389-4394

10.13417/j.gab.038.004389

81573193:国家自然科学基金 2015JJ2125:湖南省自然科学基金面上项目 CX2018B629:湖南省研究生科研创新项目

本校为第一机构

HLA-DPB1是MHC区域基因编码的跨膜糖蛋白,是人类免疫系统的重要组成部分。本研究采用生物信息数据库和分析软件对人HLA-DPB1基因的结构、单核苷酸多态性位点(SNP)、蛋白的理化特性、跨膜结构域、信号肽、亚细胞定位、二级结构、三级结构、磷酸化位点、组织表达情况及蛋白相互作用网络进行预测分析。结果表明,人HLA-DPB1基因位于6号染色体,有8种可变剪接体,SNP位点132个,其中移码突变12个,同义突变33个,错义突变87个。人HLA-DPB1蛋白由258个氨基酸组成,含有一个跨膜区和一个信号肽的亲水蛋白,主要定位于细胞内。其二级结构主要元件为无规卷曲和延伸链,三级结构预测结果可信。人HLA-DPB1蛋白有18个...

HLA-DPB1 is a transmembrane glycoprotein encoded by theMHC region and is an important part of the human immune system.In this study,Bioinformation approaches and analysis software were applied to forecast analyze humanHLA-DPB1 gene structure,single nucleotide polymorphism(SNP),protein physicochemical properties,transmembrane structure,the signal peptide,subcellular localization,secondary structure,tertiary structure,phosphorylation site,protein interaction network and tissue expression.The results showed that human HLA-DPB1 gene was located on chromosome 6.There were eight alternative transcri...