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The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate

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成果类型:
期刊论文
作者:
Yi, Shan;Liu, Yan-ping;Li, Xun-ya;Yuan, Xiao-yan;Wang, Ye;...
通讯作者:
Zhang, Zhao-hui
作者机构:
[Yi, Shan; Cai, Ying; Wang, Ye; Yuan, Xiao-yan; Zhang, Zhao-hui; Liu, Yan-ping; Huang, Lian; Li, Xun-ya; Lei, Yuan-di] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
通讯机构:
[Zhang, Zhao-hui] U
Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
16HBE cell;beryllium sulfate;bioinformatics;cytokine;miRNAs
期刊:
Journal of Applied Toxicology
ISSN:
0260-437X
年:
2020
卷:
41
期:
8
页码:
1275-1285
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573193]; Hunan Provincial Innovation Foundation For Postgraduate [CX2018B629]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ4082]
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Beryllium and its compounds are systemic toxicants that mainly accumulate in the lungs. As a regulator of gene expression, microRNAs (miRNAs) were involved in some lung diseases. This study aimed to analyze the levels of some inflammatory cytokine and the differential expressions of miRNAs in human bronchial epithelial cells (16HBE) induced by beryllium sulfate (BeSO4) and to further explore the biological functions of differentially expressed miRNAs. The profile of miRNAs in 16HBE cells was detected using the high-throughput sequencing between...

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