The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate

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成果类型：

期刊论文

作者：

Yi, Shan;Liu, Yan-ping;Li, Xun-ya;Yuan, Xiao-yan;Wang, Ye;...

通讯作者：

Zhang, Zhao-hui

作者机构：

[Yi, Shan; Cai, Ying; Wang, Ye; Yuan, Xiao-yan; Zhang, Zhao-hui; Liu, Yan-ping; Huang, Lian; Li, Xun-ya; Lei, Yuan-di] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

通讯机构：

[Zhang, Zhao-hui] U

Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

beryllium sulfate;cyclooxygenase 2;gamma interferon;inducible nitric oxide synthase;interleukin 10;let 7a 3p;microRNA;microRNA 1306;microRNA 193b;microRNA 23b;microRNA 3182;microRNA 3529 3p;microRNA 369 3p;microRNA 4485 3p;microRNA 514a 3p;microRNA 663b;microRNA 877;mitogen activated protein kinase;Rap1 protein;tumor necrosis factor;unclassified drug;vasculotropin;beryllium;beryllium sulfate;cytokine;microRNA;transcriptome;16HBE14o- cell line;Article;bioinformatics;cell viability;controlled study;down regulation;gene expression profiling;gene ontology;gene targeting;high throughput sequencing;human;human cell;IC50;MAPK signaling;pathway enrichment analysis;prediction;protein binding;real time polymerase chain reaction;signal transduction;transcription regulation;upregulation;VEGF signaling;bronchus;cell line;cell survival;cytology;drug effect;enzyme linked immunosorbent assay;metabolism;respiratory mucosa;Western blotting;Beryllium;Blotting, Western;Bronchi;Cell Line;Cell Survival;Cytokines;Enzyme-Linked Immunosorbent Assay;High-Throughput Nucleotide Sequencing;Humans;MicroRNAs;Real-Time Polymerase Chain Reaction;Respiratory Mucosa;Transcriptome

期刊：

Journal of Applied Toxicology

ISSN：

0260-437X

年：

2021

卷：

期：

页码：

1275-1285

DOI：

10.1002/jat.4116

基金类别：

Natural Science Foundation of Hunan Province, Grant/Award Number: 2020JJ4082; Hunan Provincial Innovation Foundation For Postgraduate, Grant/Award Number: CX2018B629; National Natural Science Foundation of China, Grant/Award Number: 81573193 Funding information This study was supported by the National Natural Science Foundation of China (81573193), Hunan Provincial Innovation Foundation For Postgraduate (CX2018B629), and the Natural Science Foundation of Hunan Province (2020JJ4082). This study was supported by the National Natural Science Foundation of China (81573193), Hunan Provincial Innovation Foundation For Postgraduate (CX2018B629), and the Natural Science Foundation of Hunan Province (2020JJ4082).

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Beryllium and its compounds are systemic toxicants that mainly accumulate in the lungs. As a regulator of gene expression, microRNAs (miRNAs) were involved in some lung diseases. This study aimed to analyze the levels of some inflammatory cytokine and the differential expressions of miRNAs in human bronchial epithelial cells (16HBE) induced by berylliumsulfate (BeSO4) and to further explore the biological functions of differentially expressed miRNAs. The profile of miRNAs in 16HBE cells was detected using the high-throughput sequencing between ...

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The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate

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