ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability in an In Vitro Model of Alzheimer\'s Disease Microenvironment - 成果

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ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability in an In Vitro Model of Alzheimer's Disease Microenvironment

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成果类型：

期刊论文

作者：

Zhang, Lu;Zhu, Baicheng;Zhou, Xinxin;Ning, Hao;Zhang, Fengying;...

通讯作者：

Ma, T

作者机构：

[Zhang, Lu; Zhu, Baicheng; Ma, Teng; Ma, T; Ning, Hao] China Med Univ, Sch Life Sci, Dept Neurobiol, Shenyang 110122, Peoples R China.

[Zhou, Xinxin] Liaoning Univ Tradit Chinese Med, Shenyang 110034, Peoples R China.

[Zhang, Fengying] Univ South China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang 421001, Peoples R China.

[Yan, Bingju] Jinzhou Med Univ, Affiliated Hosp 1, Dept Cardiol, Jinzhou 121000, Peoples R China.

[Chen, Jiajia] China Med Univ, Shengjing Hosp, Dept Oncol, Shenyang 110004, Peoples R China.

通讯机构：

[Ma, T ] C

China Med Univ, Sch Life Sci, Dept Neurobiol, Shenyang 110122, Peoples R China.

语种：

英文

关键词：

Alzheimer’s disease;Blood–brain barrier;HDAC1;Protein interaction;ZNF787

期刊：

Neurotoxicity Research

ISSN：

1029-8428

年：

2024

卷：

期：

页码：

1-16

DOI：

10.1007/s12640-024-00693-4

基金类别：

This work was supported by grants from the Liaoning Province Applied Basic Research Program (NO. 2022JH2/101300013), the General Project of Liaoning Province Education Department (NO. JYTMS20230121), the Natural Science Foundation of Liaoning Province of China (NO. 2021-MS-158), Project of Shenyang Science and Technology Bureau (NO. 202054071), and Project of Shenyang Municipal Health Commission (NO. 2020003).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The permeability of the blood-brain barrier (BBB) is increased in Alzheimer's disease (AD). This plays a key role in the instigation and maintenance of chronic inflammation during AD. Experiments using AD models showed that the increased permeability of the BBB was mainly caused by the decreased expression of tight junction-related proteins occludin and claudin-5. In this study, we found that ZNF787 and HDAC1 were upregulated in β-amyloid (Aβ)(1-42)-incubated endothelial cells, resulting in increased BBB permeability. Conversely, the silencin...

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ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability in an In Vitro Model of Alzheimer's Disease Microenvironment

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