Deficiency of LIGHT signaling pathway exacerbates Chlamydia psittaci respiratory tract infection in mice

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成果类型：

期刊论文

作者：

Cai, Hengling;Chen, Shenghua;Xu, Sha;Sun, Yuanbin;Bai, Qinqin;...

通讯作者：

Chen, Lili;Xu, Guilian

作者机构：

[Fu, Xizong; Bai, Qinqin; Cai, Hengling; Chen, Lili; Xu, Sha; Sun, Yuanbin] Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Lu, Chunxue; Cai, Hengling; Chen, Shenghua] Univ South China, Coll Med, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Xu, Guilian] Third Mil Med Univ, Inst Immunol, Chongqing 400038, Peoples R China.

[Chen, Yuyu] Cent S Univ, Hunan Canc Hosp, Changsha 421000, Hunan, Peoples R China.

[Chen, Yuyu] Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha 421000, Hunan, Peoples R China.

通讯机构：

[Chen, Lili] U

[Xu, Guilian] T

Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Third Mil Med Univ, Inst Immunol, Chongqing 400038, Peoples R China.

语种：

英文

关键词：

Chlamydia psittaci;LIGHT;Respiratory tract infection;T cell activation

期刊：

Microbial Pathogenesis

ISSN：

0882-4010

年：

2016

卷：

100

页码：

250-256

DOI：

10.1016/j.micpath.2016.10.006

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572011, 81001318, 30971394]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ3103]; Construct Program of the Key Discipline (Public Health and Preventive Medicine) in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

LIGHT, a costimulatory member of the immunoglobulin superfamily (Ig SF), can greatly impact T cell activation. The role of the LIGHT signaling pathway in chlamydial infection was evaluated in mice following respiratory tract infection with Chlamydia psittaci. Compared with wild type (WT) mice, LIGHT knockout (KO) mice showed significant reduction of body weight, much lower survival rate, higher bacterial burden, prolonged infection time courses and more severe pathological changes in lung tissue. The mRNA levels of IFN-gamma, TNF-alpha, IL-17 and IL-12 in the lung tissue of LIGHT KO mice were ...

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Deficiency of LIGHT signaling pathway exacerbates Chlamydia psittaci respiratory tract infection in mice

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