Lipoprotein lipase (LPL) is a key enzyme in regulation of lipoprotein metabolism, especially in breaking down plasma triglycerides (TG) of TG-rich lipoproteins, including chylomicrons and very low density lipoproteins (VLDL) .Dysfunction of LPL contributes to hypertriglyceridemia and decreased high density lipoprotein cholesterol level, which in turn increases risk of atherosclerosis. Ppromoting LPL activity inhibit atherosclerosis was once proposed and a LPL activator to validate our hypothesis was synthesized. The completed studies have shown that NO-1886 increased LPL mRNA and LPL activity ...
