期刊论文

中文

生命科学研究

1007-7847

2003

7

4

336-345

10.16605/j.cnki.1007-7847.2003.04.011

国家自然科学基金资助项目（30370675）； 日本大制药厂新药研究基金（2001 8 28）~~；

本校为第一机构

合成化合物NO-1886是一种脂蛋白脂酶活化剂,已被证明其可降低血浆TG并能升高HDL-C的浓度,后又发现其还有降低高脂高蔗糖诱发糖尿病免血浆葡萄糖浓度的作用.对高脂高蔗糖饲料喂养的小型猪脂肪细胞大小、血浆TNF-α和FFA的水平以及NO-1886对其影响进行了研究,结果发现,脂肪细胞明显肥大,血浆TNF-α和FFA以及空腹血糖水平均增高,且引起胰岛素抵抗.添加了1%NO-1886后,脂肪细胞增大被抑制,血浆TNF-α、FFA和空腹血糖的浓度均显著降低,血浆葡萄糖清除率和胰岛素分泌急性相都有了明显改善.以上结果说明,NO-1886可能通过抑制脂肪蓄积、降低血浆TNF-α和FFA的浓度而改善高脂高蔗糖饲料引起的小型猪的糖代...

The synthetic compound NO-1886 is a lipoprotein lipase activator that has been proven to be highly effective in lowering plasma triglycerides and elevating high-density lipoprotein cholesterol. It was found that NO-1886also had a plasma glucose - reducing action in high - fat / high - sucrose diet - induced diabetic rabbits. In the current study, the effects of NO-1886 on the morphology of adipocytes, plasma levels of tumor necrosis factor-α (TNF-α)and free fatty acids (FFA) in miniature pigs fed a high fat/high sucrose diet was investigated....