Pushing the envelope: Immune mechanism and application landscape of macrophage-activating lipopeptide-2

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liao, Daoyong;Su, Xiaoling;Wang, Jingyun;Yu, Jianwei;Luo, Haodang;...

通讯作者：

He, J.

作者机构：

[Luo, Haodang; He, Jun; Tian, Wei; Wang, Jingyun; Ye, Zufeng; Su, Xiaoling; Liao, Daoyong] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Clin Lab, Hengyang, Peoples R China.

[Yu, Jianwei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang, Hunan, Peoples R China.

[Luo, Haodang] Univ South China, Inst Pathogen Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Hunan Prov Key Lab Special Pathog, Hengyang, Peoples R China.

通讯机构：

[He, J.] T

The Affiliated Nanhua Hospital, China

语种：

英文

关键词：

application;immunoreaction;inflammation;macrophage-activating lipopeptide-2;Mycoplasma fermentans

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2023

卷：

页码：

1113715

DOI：

10.3389/fimmu.2023.1113715

基金类别：

This work was supported by the Scientific Research Project of Hunan Provincial Health Committee (Grant No. 20201915), the Clinical Medical Technology Innovation Guidance Project of Hunan Province (Grant No. 2020SK51901), Hengyang Science and Technology Planning Project (Grant nos. 202010021604 and 202250045307), and the Emergency special project of epidemic prevention and control of COVID-19 pneumonia in the University of South China (Grant No. 12). Acknowledgments

机构署名：

本校为第一机构

院系归属：

医学院

公共卫生学院

摘要：

Mycoplasma fermentans can cause respiratory diseases, arthritis, genitourinary tract infections, and chronic fatigue syndrome and have been linked to the development of the human immunodeficiency virus. Because mycoplasma lacks a cell wall, its outer membrane lipoproteins are one of the main factors that induce inflammation in the organism and contribute to disease development. Macrophage-activating lipopeptide-2 (MALP-2) modulates the inflammatory response of monocytes/macrophages in a bidirectional fashion, indirectly enhances the cytotoxicity of NK cells, promotes oxidative bursts in neutro...

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Pushing the envelope: Immune mechanism and application landscape of macrophage-activating lipopeptide-2

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