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Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming

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成果类型:
期刊论文
作者:
Chen, Enlin;Chen, Zhe;Chen, Linxi;Hu, Xiaoling
通讯作者:
Xiaoling Hu
作者机构:
[Hu, Xiaoling; Chen, Enlin] Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China
[Chen, Zhe; Chen, Linxi] Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, College of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, China
通讯机构:
[Xiaoling Hu] D
Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China
语种:
英文
关键词:
Mitochondria;stem cells;wound healing
期刊:
Platelets
ISSN:
0953-7104
年:
2022
卷:
33
期:
2
页码:
171-173
基金类别:
ScientificResearchFundProjectofHunanProvincialHealthCommission#&#&#20201901 NaturalScienceFoundationofHunanProvince#&#&#2019JJ40255 NaturalScienceFoundationofHunanProvince#&#&#2019JJ50523
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Mitochondria regulate intracellular metabolism and are also involved in intercellular transfer in vitro and in vivo, thereby affecting the function of adjacent cells. Mitochondria can also be transferred to various differentiated cells to improve their respiratory function, ATP production, as well as protect damaged cells from apoptosis. Both in vivo and in vitro, mitochondria can be transferred from one cell to another to regulate cellular metabolism under physiological or pathophysiological conditions, referred to as "mitochondrial translocation". Mitochondrial translocation is associated in...

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