Forkhead box protein A1 inhibits the expression of uncoupling protein 2 in hydrogen peroxide-induced A549 cell line

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成果类型：

期刊论文

作者：

Song, Lan*;Xu, Zhaojun;Li, Ling;Hu, Mei;Cheng, Lijuan;...

通讯作者：

Song, Lan

作者机构：

[Hu, Mei; Zhang, Bo; Chen, Lingli; Song, Lan; Cheng, Lijuan] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Song, Lan] Univ South China, Coll Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Xu, Zhaojun] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 41007, Hunan, Peoples R China.

[Li, Ling] Hunan Univ Tradit Chinese Med, Preclin Med Teaching & Expt Ctr, Coll Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Song, Lan] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Coll Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Song, Lan] H

Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Coll Med, 1 Xiangzui Rd,Hanpu Sci & Teching Pk, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Forkhead box protein A1;UCP2;Gene expression;Hydrogen peroxide

期刊：

CELL STRESS & CHAPERONES

ISSN：

1355-8145

年：

2014

卷：

期：

页码：

53-60

DOI：

10.1007/s12192-013-0433-z

基金类别：

Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000026, 81202451]; National Science Foundation for post-doctoral Scientists of Cnina [2012M511731]; Research Fund for the Doctoral program of Higher Education of ChinaResearch Fund for the Doctoral Program of Higher Education of China (RFDP)Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20114323120002]; National Nature Science Foundation of Hunan, China [12JJ4029]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Forkhead box protein A1 (FoxA1) is a transcription factor that is involved in embryonic development and cell differentiation. In this study, we show that hydrogen peroxide (H2O2) treatment upregulated expression of FoxA1 and UCP2 in the A549 cell line. Overexpression of FoxA1 by full-length complementary DNA reduced UCP2 expression, while silencing of FoxA1 expression by small interfering RNA significantly increased UCP2 levels. FoxA1 binds to a site from -919 to -913 bp relative to the UCP2 transcription start site. The overexpression of FoxA1...

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Forkhead box protein A1 inhibits the expression of uncoupling protein 2 in hydrogen peroxide-induced A549 cell line

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