The influence of HK2 blood group antigen on human B cell activation for ABOi-KT conditions

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成果类型：

期刊论文

作者：

Cao, Jingsong;Liu, Luogen;Zhang, Yunsheng;Xiao, Jianhua*;Wang, Yi*

通讯作者：

Xiao, Jianhua;Wang, Yi

作者机构：

[Xiao, Jianhua; Cao, Jingsong] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Jianhua; Cao, Jingsong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Wang, Yi; Zhang, Yunsheng; Xiao, JH; Wang, Y; Xiao, Jianhua; Liu, Luogen; Cao, Jingsong] Univ South China, Affiliated Hosp 2, Inst Pathogen Biol, Clin Res Ctr,Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Wang, Yi] Univ South China, Affiliated Hosp 2, Urinary Surg, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, Jianhua; Xiao, JH; Wang, Y] U

Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Inst Pathogen Biol, Clin Res Ctr,Med Coll, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Blood group B antigen;Blood group B antibody;HK2;B cells activation;ABOi-KT

期刊：

BMC Immunology

ISSN：

1471-2172

年：

2017

卷：

期：

页码：

1-8

DOI：

10.1186/s12865-017-0233-9

基金类别：

This work was supported by the Zhengxiang scholar program of the University of South China.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background: It is well known that ABO blood group system incompatible kidney transplantation (ABOi-KT) is an effective strategy for end-stage renal disease. The main barrier for ABOi-KT is how to keep host B cell activation and blood group antibody titer in low levels. Moreover, the mechanism of B cell activation induced by blood group antigen was unclear in ABOi-KT. Results: In this study, HK2 cells were identified to express blood group B antigen when cocultured with lymphocytes of blood group A. Optical microscope observation demonstrated th...

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The influence of HK2 blood group antigen on human B cell activation for ABOi-KT conditions

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