The influence of HK2 blood group antigen on human B cell activation for ABOi-KT conditions

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成果类型：

期刊论文

作者：

Cao, Jingsong;Liu, Luogen;Zhang, Yunsheng;Xiao, Jianhua*;Wang, Yi*

通讯作者：

Xiao, Jianhua;Wang, Yi

作者机构：

[Xiao, Jianhua; Cao, Jingsong] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Jianhua; Cao, Jingsong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Wang, Yi; Zhang, Yunsheng; Xiao, JH; Wang, Y; Xiao, Jianhua; Liu, Luogen; Cao, Jingsong] Univ South China, Affiliated Hosp 2, Inst Pathogen Biol, Clin Res Ctr,Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Wang, Yi] Univ South China, Affiliated Hosp 2, Urinary Surg, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, Jianhua; Xiao, JH; Wang, Y] U

Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Inst Pathogen Biol, Clin Res Ctr,Med Coll, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Blood group B antigen;Blood group B antibody;HK2;B cells activation;ABOi-KT

期刊：

BMC Immunology

ISSN：

1471-2172

年：

2017

卷：

期：

页码：

1-8

DOI：

10.1186/s12865-017-0233-9

基金类别：

This work was supported by the Zhengxiang scholar program of the University of South China.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

It is well known that ABO blood group system incompatible kidney transplantation (ABOi-KT) is an effective strategy for end-stage renal disease. The main barrier for ABOi-KT is how to keep host B cell activation and blood group antibody titer in low levels. Moreover, the mechanism of B cell activation induced by blood group antigen was unclear in ABOi-KT. In this study, HK2 cells were identified to express blood group B antigen when cocultured with lymphocytes of blood group A. Optical microscope observation demonstrated that HK2 cells in coculture group gradually decreased. Furthermore, flow ...

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The influence of HK2 blood group antigen on human B cell activation for ABOi-KT conditions

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