Integrated Analysis of the Functions and Prognostic Values of RNA-Binding Proteins in Colorectal Cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Ya;Chen, Yuqiao;Xiao, Shuai*;Fu, Kai*

通讯作者：

Fu, Kai;Xiao, Shuai

作者机构：

[Fu, Kai; Wang, Ya; Chen, Yuqiao] Cent South Univ, Xiangya Hosp, Inst Mol Precis Med, Changsha, Peoples R China.

[Fu, Kai; Wang, Ya; Chen, Yuqiao] Cent South Univ, Xiangya Hosp, Hunan Key Lab Mol Precis Med, Changsha, Peoples R China.

[Fu, Kai; Wang, Ya; Chen, Yuqiao] Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Peoples R China.

[Xiao, Shuai] Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, Hengyang, Peoples R China.

[Xiao, Shuai] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang, Peoples R China.

通讯机构：

[Fu, Kai] C

[Xiao, Shuai] U

Cent South Univ, Xiangya Hosp, Inst Mol Precis Med, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp, Hunan Key Lab Mol Precis Med, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Peoples R China.

语种：

英文

关键词：

colorectal cancer;overall survival;prognostic signature;regulatory network;RNA-binding protein

期刊：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

ISSN：

2296-634X

年：

2020

卷：

页码：

595605

DOI：

10.3389/fcell.2020.595605

基金类别：

The authors thank all patients, investigators, and institutions involved in these studies, especially the Cancer Genome Atlas Program. Funding. This work was supported in part by grants 31900561 from National Natural Science Foundation of China, Innovation-driven Projects 2020CX016 from Central South University, Huxiang Talent Aggregation Project 2018RS3027 and 2019RS1010 from Hunan Provincial Science and Technology Department (China). YW was supported by Xiangya Hospital Central South University Postdoctoral Foundation. SX is supported by grant 81702949 from National Natural Sciences Foundation of China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Colorectal cancer (CRC) is one of the most common malignant tumors. Selecting effective treatment for CRC patients, especially in the early stages, remains a challenge because of the lack of adequate biomarkers. Recent evidence suggests that RNA-binding proteins (RBPs) play a vital role in development and progression of carcinogenesis. However, their mechanisms in cancer progression are still limited. The role of RBPs in CRC has been poorly understood. There were 1,542 reported RBPs analyzed between CRC tissues and normal tissues using the Wilc...

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Integrated Analysis of the Functions and Prognostic Values of RNA-Binding Proteins in Colorectal Cancer

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