Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

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成果类型：

期刊论文

作者：

Jing, Qiancheng;Li, Guo;Chen, Xiyu;Liu, Chao;Lu, Shanhong;...

通讯作者：

Qiu, Yuanzheng;Liu, Yong

作者机构：

[Zhang, Shuiting; Lu, Shanhong; Qin, Yuexiang; Liu, Chao; Ma, Huiling; Chen, Xiyu; Zheng, Hua; Li, Guo; Zhang, Diekuo; Qiu, Yuanzheng; Jing, Qiancheng; Huang, Donghai; Liu, Yong; Ren, Shuling; Qiu, YZ] Cent S Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Zhang, Shuiting; Lu, Shanhong; Qin, Yuexiang; Liu, Chao; Ma, Huiling; Chen, Xiyu; Zheng, Hua; Li, Guo; Zhang, Diekuo; Qiu, Yuanzheng; Jing, Qiancheng; Huang, Donghai; Liu, Yong; Ren, Shuling] Otolaryngol Major Dis Res Key Lab Hunan Prov, Changsha, Hunan, Peoples R China.

[Jing, Qiancheng] Univ South China, Changsha Cent Hosp, Dept Otolaryngol Head & Neck Surg, Changsha, Hunan, Peoples R China.

[Qin, Yuexiang] Cent S Univ, Xiangya Hosp 3, Hlth Management Ctr, Changsha, Hunan, Peoples R China.

[Chen, Jie; Tan, Pingqing] Cent S Univ, Affiliated Tumor Hosp, Xiangya Med Sch, Hunan Canc Hosp,Dept Head & Neck Surg, Changsha, Hunan, Peoples R China.

通讯机构：

[Qiu, YZ; Liu, Y] C

Cent S Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

autophagy;prognosis;radioresistance;squamous cell carcinoma of the head and neck;Wnt3a

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2019

卷：

期：

页码：

4711-4722

DOI：

10.1111/jcmm.14394

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602684, 81773243, 81874133]; Xiangya Hospital-Sinobioway Clinic and rehabilitation Research Foundation [XYWM2015123]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ3488, 2018JJ2630]; Huxiang Young Talent Project [2018RS3024]; National Key Research and Development Program of China [2016YFC0902003]

机构署名：

本校为其他机构

摘要：

The canonical Wnt/β-catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt-mediated autophagy in cancer radioresistance remains unclear. In this study, we found that irradiation activated the Wnt/β-catenin and autophagic signalling pathways in squamous cell carcinoma of the head and neck (SCCHN). Wnt3a is a classical ligand that activated the Wnt/β-catenin signalling pathway, induced autophagy and decreased the sensitivity of SCCHN to irradiation both in vitro and in vivo. Further mechani...

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Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

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