Intrathecal Injection of Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorates Neuropathic Pain in Rats

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成果类型：

期刊论文

作者：

Chen, Chunxiu;Chen, Fengfeng;Yao, Chengye;Shu, Shaofang;Feng, Juan;...

通讯作者：

Chen, Xiangdong

作者机构：

[Chen, Chunxiu; Feng, Juan; Yao, Shanglong; Chen, Xiangdong; Yao, Chengye; Shu, Shaofang] Huazhong Univ Sci & Technol, Inst Anesthesiol & Crit Care Med, Union Hosp, Dept Anesthesiol,Tongji Med Coll, Wuhan, Peoples R China.

[Chen, Fengfeng] Sichuan Univ, West China Hosp, Dept Radiol, Huaxi MR Res Ctr, Chengdu, Peoples R China.

[Hu, Xiaoling; Feng, Juan] Univ South China, Dept Anesthesia, Affiliated Hosp 1, Henyang, Peoples R China.

[Hai, Quan] Sichuan Prov Regenerat Med Engn Technol Res Ctr, Chengdu, Peoples R China.

通讯机构：

[Chen, Xiangdong] H

Huazhong Univ Sci & Technol, Inst Anesthesiol & Crit Care Med, Union Hosp, Dept Anesthesiol,Tongji Med Coll, Wuhan, Peoples R China.

语种：

英文

关键词：

Neuropathic pain;Spinal nerve ligation;Mesenchymal stem cells;Astrocyte;Microglia

期刊：

Neurochemical Research

ISSN：

0364-3190

年：

2016

卷：

期：

页码：

3250-3260

DOI：

10.1007/s11064-016-2051-5

基金类别：

National Natural Science Foundation of China (Beijing, China)National Natural Science Foundation of China (NSFC) [81171274, 81571075]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Neuropathic pain (NP) is a clinically incurable disease with miscellaneous causes, complicated mechanisms and available therapies show poor curative effect. Some recent studies have indicated that neuroinflammation plays a vital role in the occurrence and promotion of NP and anti-inflammatory therapy has the potential to relieve the pain. During the past decades, mesenchymal stem cells (MSCs) with properties of multipotentiality, low immunogenicity and anti-inflammatory activity have showed excellent therapeutic effects in cell therapy from animal models to clinical application, thus aroused g...

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