期刊论文

Peng, Tianhong;Lv, Yuncheng

英文

DNA AND CELL BIOLOGY

1044-5498

2017

36

12

1050-1061

10.1089/dna.2017.3853

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81770460, 81570408), the Postdoctoral Research Fellowship of Saskatchewan Health Research Foundation (SHRF, 4144), the Hunan Provincial Natural Science Foundation of China (14JJ2091), the Scientific Research Fund of Hunan Provincial Education Department (12C0339, 10C1178), the start-up funds for PhDs in University of South China (2014XQD37), Zhengxiang scholar program (Prof. Xiangyang Tang) of the University of South China, and the Construct Program of the Key Discipline in Hunan Province.

本校为第一且通讯机构

The present review provides a summary of recent evidence of sortilin expression, function, and regulation and its implications in lipid metabolism and development of lipid disorder diseases. As a member of the vacuolar protein sorting 10 protein (Vps10p) receptor family, sortilin mediates intracellular trafficking of diverse endogenous or exogenous protein substrates between the trans-Golgi network (TGN) and plasma membrane compartments. Recent studies reveal that sortilin regulates the expression of lipid genes, plasma lipid level, and the development of lipid disorder diseases. Sortilin prom...