Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Huan;He, Shiqing;Li, Chong;Wang, Jianpeng;Zou, Qin;...

通讯作者：

Rui Chen

作者机构：

[Liu, Huan] Univ South China, Affiliated Nanhua Hosp, Dept Cardiol, Hengyang, Peoples R China.

[Zou, Qin; Li, Chong; Wang, Jianpeng; Liao, Yongshi; He, Shiqing; Chen, Rui] Univ South China, Affiliated Nanhua Hosp, Dept Neurosurg, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Rui Chen] D

Department of Neurosurgery, Affiliated Nanhua Hospital, University of South China, Hengyang, China

语种：

英文

关键词：

apoptosis;CHOP;JNK;TBI;Tetrandrine

期刊：

Brain and Behavior

ISSN：

2162-3279

年：

2022

卷：

期：

页码：

e2786

DOI：

10.1002/brb3.2786

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province (2021JJ70045 and 2022JJ30544), and the Clinical Medical Technology Innovation Guidance Project of Hunan Province (No. 2020SK51909).

机构署名：

本校为第一机构

摘要：

Aim: The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method: Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects. The expression of neuron-specific enolase (NSE), Caspase 3, and Caspase 12 was detected by immunofluorescence. The expression of TNF-α, NF-κB, TRAF1, ERS markers (GADD34 and p-PERK), IRE1α, CHOP, JNK, and p-JNK were evaluated by western blot. Flow cytometry was used t...

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Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

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