期刊论文

Ma, Teng;Zhou, Ping-Kun

英文

Biochemical and Biophysical Research Communications

0006-291X

2017

483

1

223-229

10.1016/j.bbrc.2016.12.162

This work was supported by the grants from National Key Basic Research Program (973 Program) of MOST, China (Grant No. 2015CB910601), the National Natural Science Foundation of China (Grant No. 31370843, 31500681) to P.K Zhou and the National Natural Science Foundation of China (31570853 and 81602799) T.Ma.

本校为其他机构

Like ubiquitination, several studies have demonstrated that neddylation is implicated to be involved in the double strand break repair. BRCA1 is one of the key repair factors in the homologous recombination repair and may play a downstream role of the neddylation. BRCA1 is also a frequently mutated gene in cancers, which serve as the targets for PARP inhibitors. Here we further investigated the correlation between neddylation and BRCA1 complex using neddylation inhibitor MLN4924. MLN4924 efficiently inhibited the recruitment of components of BR...