UPLC-QqQMS based targeted metabolomics reveal combination impact on metabolism caused by bisphenol AF and fructose combined exposure in male mice

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成果类型：

期刊论文

作者：

Li, Yuan;Chen, Junmin;Liu, Xiaocheng;Liu, Xu;Yang, Qing;...

通讯作者：

Rang, Ouyan;Wang, M

作者机构：

[Li, Yuan; Liu, Xiaocheng; Rang, Ouyan; Liu, Xu; Li, Guojuan; Wang, Mu; Yang, Qing] Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang Med Sch,Nucl Ind Hyg Sch,Dept Basic Med, Hengyang 421001, Hunan, Peoples R China.

[Chen, Junmin] Univ South China, Affiliated Nanhua Hosp, Hlth Sch Nucl Ind, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Xu] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Rang, O; Wang, M ] U

Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab,Clin Res Inst, Hengyang Med Sch,Nucl Ind Hyg Sch,Dept Basic Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

BPAF;Combination impact;Fructose;Targeted metabolomics

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2025

卷：

期：

页码：

13800

DOI：

10.1038/s41598-025-98814-2

基金类别：

Key Project of Hunan Provincial Natural Science Foundation [2025JJ30049]; Key Project of Hunan provincial science and technology innovation [2020sk1012]; Natural Science Foundation of Hunan Province [2022JJ30547]; Excellent youthful project Scientific research of Hunan Provincial Department of Education [20B491]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Bisphenol AF (BPAF), a fluorinated alternative to the plasticizer bisphenol A (BPA), is found in both the environment and the human body. Fructose is one of the sweeteners that has been widely used in recent years. Prior research has verified that the combined exposure to fructose and BPA considerably worsened the impact on glycolipid metabolism. However, it is currently unclear whether BPAF have a combination effect on health with fructose. Serum glucose and insulin, liver biochemistry, histology of the liver and adipose tissue, serum profiles...

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UPLC-QqQMS based targeted metabolomics reveal combination impact on metabolism caused by bisphenol AF and fructose combined exposure in male mice

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