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Comprehensive multiomics profiling reveals the protective function of gypenosides against dextran sulfate sodium-induced colitis.

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成果类型:
期刊论文
作者:
Yang, Yuan;Li, Xinyuan;Huang, Fan;Cai, Fuchao;Ning, Xufeng;...
作者机构:
[Li, Xinyuan; Yang, Yuan; Jiang, Qilin; Ning, Xufeng; Cai, Fuchao; Huang, Fan] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China
[Zhou, Lingshan] Department of Geriatrics Ward 2, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China
[Zeng, Bin] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. zbss1229@163.com
[Zhou, Weiwei] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. 543906753@qq.com
[Hu, Guangsheng] Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. 360680725@qq.com
语种:
英文
关键词:
Colitis;Gypenosides;Metabolomics;Stemness;Transcriptome
期刊:
Scientific Reports
ISSN:
2045-2322
年:
2025
卷:
15
期:
1
页码:
31803
机构署名:
本校为第一机构
摘要:
In this study, we determined whether gypenosides exert a therapeutic effect on colitis. We then explored the underlying mechanism of gypenosides in the treatment of ulcerative colitis (UC) via multiomics analyses. Dextran sulfate sodium (DSS) was used to establish a UC model in mice, and a subgroup of colitis model mice was subjected to gypenosides intervention. The inflammatory manifestations of the model and drug groups were determined via histological and molecular experiments. In addition, tissue and blood samples were collected for transcriptome and metabolomics analysis, respectively. Im...

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