Serglycin Is a Theranostic Target in Nasopharyngeal Carcinoma that Promotes Metastasis

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成果类型：

期刊论文

作者：

Li, Xin-Jian;Ong, Choon Kiat;Cao, Yun;Xiang, Yan-Qun;Shao, Jian-Yong;...

通讯作者：

Qian, Chao-Nan

作者机构：

[Qian, Chao-Nan; Zeng, Yi-Xin; Shao, Jian-Yong; Zheng, Fang-Jing; Kang, Tie-Bang; Li, Xin-Jian; Lu, Wen-Hua; Bao, Ying-Na; Cao, Yun; Peng, Li-Xia] Sun Yat Sen Univ, State Key Lab Oncol S China, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China.

[Qian, Chao-Nan; Xiang, Yan-Qun] Sun Yat Sen Univ, Dept Nasopharyngeal Carcinoma, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China.

[Shao, Jian-Yong; Cao, Yun] Sun Yat Sen Univ, Dept Pathol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China.

[Qin, Li] Univ S China, Div Pharmacoprote, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Qian, Chao-Nan; Teh, Bin Tean; Ong, Choon Kiat] Natl Canc Ctr Singapore, NCCS VARI Translat Res Program, Singapore, Singapore.

通讯机构：

[Qian, Chao-Nan] S

Sun Yat Sen Univ, Dept Nasopharyngeal Carcinoma, Ctr Canc, 651 Dongfeng E Rd, Guangzhou 510060, Guangdong, Peoples R China.

语种：

英文

期刊：

Cancer Research

ISSN：

0008-5472

年：

2011

卷：

期：

页码：

3162-3172

DOI：

10.1158/0008-5472.CAN-10-3557

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81030043, 81000946]; National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [20060102A4002]; Major State Basic Research Program of China (973)National Basic Research Program of China [2006CB910104]; National Cancer Center Research Foundation of Singapore; Singapore Millennium FoundationSingapore Millennium Foundation; Van Andel Foundation

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Nasopharyngeal carcinoma (NPC) is known for its high-metastatic potential. Here we report the identification of the proteoglycan serglycin as a functionally significant regulator of metastasis in this setting. Comparative genomic expression profiling of NPC cell line clones with high- and low-metastatic potential revealed the serglycin gene (SRGN) as one of the most upregulated genes in highly metastatic cells. RNAi-mediated inhibition of serglycin expression blocked serglycin secretion and the invasive motility of highly metastatic cells, redu...

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Serglycin Is a Theranostic Target in Nasopharyngeal Carcinoma that Promotes Metastasis

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