Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery

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成果类型：

期刊论文

作者：

Sun, Lu;Wei, Hua*;Zhang, Xianshuo;Meng, Chao;Kang, Guiying;...

通讯作者：

Wei, Hua;Yu, Cuiyun

作者机构：

[Wei, Hua; Ma, Wei; Ma, Liwei; Zhang, Xianshuo; Sun, Lu; Wang, Baoyan; Meng, Chao; Kang, Guiying] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Ma, Wei; Ma, Liwei; Zhang, Xianshuo; Sun, Lu; Wang, Baoyan; Meng, Chao; Kang, Guiying] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Wei, H; Yu, Cuiyun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Wei, H; Yu, Cuiyun] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Wei, Hua] L

[Wei, H; Yu, CY] U

Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Polymer Chemistry

ISSN：

1759-9954

年：

2020

卷：

期：

页码：

4469-4476

DOI：

10.1039/d0py00653j

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [51473072, 21504035]; Thousand Young Talent Program; Outstanding Youth Fund of Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ1024]; National Key R&D Program of China [2018YFB1900201]; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Conjugation of folic acid (FA) onto the surface of nanocarriers for active targeting is the mainstream strategy to improve the targeting efficiency of delivery vehicles for enhanced anticancer drug delivery; however, this strategy suffers from the fast clearance of nanocarriers caused by an immunological response and the nonspecific cellular uptake of nanocarriers compromising therapeutic efficiency and causing serious side effects. To address this dilemma, a dual-functional sheddable monomethoxypolyethylene glycol (mPEG) stealth component for ...

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Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery

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