Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Zhao, Guo-jun;Mo, Zhong-Cheng;Tang, Shi-Lin;Ouyang, Xin-Ping;He, Ping-ping;...

通讯作者：

Tang, Chao-ke

作者机构：

[Ouyang, Xin-Ping; Shi, Jin-Feng; Zhang, Min; Liu, Dan; Zhao, Guo-jun; Tang, Chao-ke; Tan, Yu-lin; Lv, Yun-cheng; He, Ping-ping; Xie, Wei; Yao, Feng] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Peoples R China.

[Zhao, Guo-jun] Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Guangxi, Peoples R China.

[Mo, Zhong-Cheng] Univ South China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shi-Lin] Univ South China, Affiliated Hosp 1, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.

[Tian, Guo-Ping; Wang, Yan] Univ South China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-ke] U

Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

ABCA1;Atherosclerosis;Chlamydia pneumoniae;NF-kappaB;TLR2;miR-33s

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2014

卷：

235

期：

页码：

519-525

DOI：

10.1016/j.atherosclerosis.2014.05.943

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81200218, 81070220, 81370377, 81170278]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [14JJ5016, 14JJ2084]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; construct program of the key discipline in Hunan Province, China

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Objectives: ATP-binding cassette transporter A1 (ABCA1) is critical in exporting cholesterol from macrophages and plays a protective role in the development of atherosclerosis. This study was to determine the effects and potential mechanisms of Chlamydia pneumoniae (C. pneumoniae) on ABCA1 expression and cellular cholesterol efflux in THP-1 macrophage-derived foam cells. Methods and results: C. pneumoniae significantly decreased the expression of ABCA1 and reduced cholesterol efflux. Furthermore, we found that C. pneumoniae suppressed ABCA1 expression via upregulation of miR-33s. The inhibitio...

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Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells

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