期刊论文

Jiang, Zhi-Sheng

英文

Clinica Chimica Acta

0009-8981

2014

437

106-114

10.1016/j.cca.2014.07.019

This work was supported by grants from the National Natural Science Foundation of China ( 81170277 to Z.-S.J. and 81100106 to C.Z.), by the Special Research Fund for the Doctoral Program of Higher Education of China Project ( 20124324110003 to Z.-S.J.), and by the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province .

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Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD+-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying molecular mechanisms, including inhibition of oxidative stre...