期刊论文

Zhong, Cai-Gao;Pei, Hua-Dong

英文

Cancer Medicine

2045-7634

2017

6

2

483-493

10.1002/cam4.995

The authors thank Dr. Susan Smith (Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, USA) and Dr Zhenkun Lou (Division of Oncology Research, Mayo Clinic Rochester, USA) for kindly providing the PLPC-Myc-TNK1BP1 expression plasmids and HR and NHEJ reporter plasmids. We also thank National Center for Protein Sciences Beijing (PHOENIX Center) and Z Fu for assistance for FACS and Ping Wu's help for fluorescence microscope. This work was sponsored by the National Key Basic Research Program (973 Program) of MOST, China (Grant No. 2015CB910601), the Chinese National Natural Science Foundation (Grant No. 81173081, 81473005).

本校为其他机构

TNKS1BP1 is a member of the poly(ADP-ribose) polymerase (PARP) superfamily. Our previous studies have demonstrated that TNKS1BP1 plays an important role in DNA damage response. But whether and how TNKS1BP1 associates with cancer is still not clear. Here, we found that TNKS1BP1 was upregulated in human lung adenocarcinoma (LAC) tissues, and was associated with poor overall survival (OS) in LAC patients. Dysregulation of TNKS1BP1 affected the sensitivity of A549 cells to several DNA damage agents including cisplatin, bleomycin, and ionizing radiation. Mechanically, overexpression of TNKS1BP1 inc...