Click-Reaction-Mediated Chemotherapy and Photothermal Therapy Synergistically Inhibit Breast Cancer in Mice

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成果类型：

期刊论文

作者：

Zhang, Guiquan;Chen, Xuemei;Chen, Xu;Du, Kaihong;Ding, Keke;...

通讯作者：

Hu, Rong;Qin, AJ;Hu, R

作者机构：

[Du, Kaihong; Chen, Xuemei; Qin, Anjun; Chen, Xu; Qin, AJ; Zhang, Guiquan; Hu, Rong; Hu, R] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.

[Du, Kaihong; Chen, Xuemei; Qin, Anjun; Chen, Xu; Qin, AJ; Zhang, Guiquan; Hu, Rong; Hu, R; Tang, Ben Zhong] South China Univ Technol, AIE Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China.

[Ding, Keke; He, Dong] SooChow Univ, Affiliated Hosp 1, Dept Urol, Suzhou 215006, Jiangsu, Peoples R China.

[Ding, Dan] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.

[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China.

通讯机构：

[Qin, AJ ; Hu, R] S

[Hu, R ] U

South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.

South China Univ Technol, AIE Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China.

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Synergistic treatment;Photothermal immunotherapy;Chemotherapy;Immunogenic cell death;Immunotherapy

期刊：

ACS Nano

ISSN：

1936-0851

年：

2023

卷：

期：

页码：

14800-14813

DOI：

10.1021/acsnano.3c03005

基金类别：

National Natural Science Foundation of China [21788102, 21907034]; National Natural Science Foundation of China [2019B030301003, 2016A030312002]; Natural Science Foundation of Guangdong Province [2017YFE0132200]; National Key Research and Development Program of China (Intergovernmental Cooperation Project) [ITC-CNERC14SC01]; Innovation and Technology Commission of Hong Kong

机构署名：

本校为通讯机构

院系归属：

化学化工学院

摘要：

The development of functional materials for tumor immunogenicity enhancement is desirable for overcoming the low therapeutic efficiency and easy metastasis during tumor treatments. Herein, the thermoresponsive nanoparticles composed of photothermal agent (PTA) and click reactive reagent are developed for enhanced immunotherapy application. A Ni-bis(dithiolene)-containing PTA with intense near-infrared absorption and efficient photothermal conversion is developed for thermoresponsive nanoparticles construction. The generated heat by encapsulated PTA further induces the phase transition of therm...

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Click-Reaction-Mediated Chemotherapy and Photothermal Therapy Synergistically Inhibit Breast Cancer in Mice

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