Cis-Cardio: A comprehensive analysis platform for cardiovascular-relavant cis-regulation in human and mouse

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成果类型：

期刊论文

作者：

Song, Chao;Zhang, Yuexin;Huang, Hong;Wang, Yuezhu;Zhao, Xilong;...

通讯作者：

Li, Chunquan;Tang, HF

作者机构：

[Zhang, Yuexin; Wang, Qiuyu; Zhang, Guorui; Song, Chao; Huang, Hong; Tang, Huifang; Yin, Mingxue; Li, Chunquan; Shang, Desi; Liu, Jiaqi; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Inst Cardiovasc Dis, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Wang, Qiuyu; Zhang, Guorui; Song, Chao; Huang, Hong; Tang, Huifang; Yin, Mingxue; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Artificial Intel, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Wang, Qiuyu; Zhang, Guorui; Song, Chao; Huang, Hong; Tang, Huifang; Yin, Mingxue; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Hunan Prov Key Lab Multi & Artificial Intelligence, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Song, Chao; Tang, Huifang; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Wang, Qiuyu; Song, Chao; Huang, Hong; Tang, Huifang; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, Hengyang, Peoples R China.

通讯机构：

[Li, CQ; Tang, HF ] U

Univ South China, Affiliated Hosp 1, Inst Cardiovasc Dis, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MT: Bioinformatics;cardiovascular;cis-regulation;platform;transcription regulation

期刊：

Molecular Therapy - Nucleic Acids

ISSN：

2162-2531

年：

2023

卷：

页码：

655-667

DOI：

10.1016/j.omtn.2023.07.030

基金类别：

National Natural Science Foundation of China; Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [62171166]; China Post-doctoral Science Foundation [20210002-1005 USCAT-2021-01]; Natural Science Foundation of Hunan Province [2019M661311, 2023JJ30547, 2023JJ40594]; Scientific Research Fund Project of Hunan Provincial Health Commission [2023JJ30536]; Special Funds for the Construction of Innovative Provinces in Hunan [20201920]; Clinical Research 4310 Program of the University of South China [2020SK4008, 20214310NHYCG03]; [20224310NHYCG05]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Cis-regulatory elements are important molecular switches in controlling gene expression and are regarded as determinant hubs in the transcriptional regulatory network. Collection and processing of large-scale cis-regulatory data are urgent to decipher the potential mechanisms of cardiovascular diseases from a cis-regulatory element aspect. Here, we developed a novel web server, Cis-Cardio, which aims to document a large number of available cardiovascular-related cis-regulatory data and to provide analysis for unveiling the comprehensive mechanisms at a cis-regulation level. The current version...

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Cis-Cardio: A comprehensive analysis platform for cardiovascular-relavant cis-regulation in human and mouse

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