The JAK-STAT3 signaling pathway is a key regulator of cell growth,motility,migration,invasion and apoptosis in mammalian cells.Infection with intracellular pathogens of the genus Chlamydia can inhibit host cell apoptosis,and here we asked whether the JAK-STAT3 pathway participates in chlamydial anti-apoptotic activity.We found that,compared with uninfected cells,levels of JAK1 and STAT3 mRNA as well as total and phosphorylated JAK1 and STAT3 protein,were ...
